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Prandin (Repaglinide) Description
Repaglinide is used for:
Managing type 2 (non-insulin-dependent) diabetes. It is used in addition to diet and exercise to lower blood sugar in adults who cannot manage with diet, exercise, or diabetic medications alone. It may be used with other diabetes medicines.
Repaglinide is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. Repaglinide does not work in type 1 (insulin-dependent) diabetes, because in this condition the pancreas gland is not capable of making or releasing insulin.
Do NOT use Repaglinide if:
- you are allergic to any ingredient in Repaglinide
- you have type 1 diabetes (insulin-dependent diabetes) or have elevated ketone levels due to diabetes
- you are also taking gemfibrozil
Contact your doctor or health care provider right away if any of these apply to you.
Before using Repaglinide :
Some medical conditions may interact with Repaglinide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription medicine, nonprescription medicine, herbal preparation or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of acidosis, kidney disease, or liver disease
Some MEDICINES MAY INTERACT with Repaglinide. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Rifampin because the effectiveness of Repaglinide may be decreased
- Beta blockers (eg, propranolol), gemfibrozil, imidazoles (eg, ketoconazole), macrolides and ketolides (eg, erythromycin, azithromycin), monoamine oxidase (MAO) inhibitors (eg, phenelzine), quinolones (eg, ciprofloxacin), or salicylates (eg, aspirin) because side effects, such as low blood sugar,
may be increased
- Insulin because it may increase the risk of side effects of Repaglinide
This may not be a complete list of all interactions that may occur. Ask your health care provider if Repaglinide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Repaglinide :
Use Repaglinide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Repaglinide 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal. If you add an extra meal, take an extra dose with that meal.
- If you miss a dose of Repaglinide , skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Repaglinide.
Important safety information:
- Fever, injury, infection, or surgery may affect your diabetes control. If any of these occur, check with your doctor.
- Diabetes patients - Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor?s directions. If your blood sugar level is often higher than it should be and you are taking Repaglinide according to directions, check
with your doctor.
- Diabetes patients - Repaglinide may cause low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, or fainting). It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you do
not have a reliable source of glucose available, eat a quick source of
sugar such as table sugar, honey, or candy, or drink a glass of orange
juice or non-diet soda to quickly raise your blood sugar level. Tell your
doctor immediately about the reaction. To prevent hypoglycemia, eat meals
on a regular schedule and do not skip meals.
- Carefully follow the diet and exercise program prescribed by your health care provider.
- Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Repaglinide.
- LAB TESTS, such as liver and kidney function tests, fasting blood sugar, glycosylated hemoglobin, or complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab test appointments.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Repaglinide during pregnancy. It is unknown if Repaglinide is excreted in breast milk. Do not breast-feed while you are taking Repaglinide.
Possible side effects of Repaglinide :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Changes in vision; diarrhea; headache; increased heartbeat; increased hunger; joint or back pain; nasal or chest congestion; nervousness; sinus inflammation; sweating; tiredness; tremor.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain.
What is the shelf life of the pills?
- The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
Diabetes, Type 2 Medications
Definition of Diabetes, Type 2: Type 2 diabetes is characterized by "insulin resistance" as body cells do not respond appropriately when insulin is present. This is a more complex problem than type 1, but is sometimes easier to treat, since insulin is still produced, especially in the initial years. Type 2 may go unnoticed for years in a patient before diagnosis, since the symptoms are typically milder (no ketoacidosis) and can be sporadic. However, severe complications can result from unnoticed type 2 diabetes, including renal failure, and coronary artery disease. Type 2 diabetes was formerly known by a variety of partially misleading names, including "adult-onset diabetes", "obesity-related diabetes", "insulin-resistant diabetes", or "non-insulin-dependent diabetes" (NIDDM). It may be caused by a number of diseases, such as hemochromatosis and polycystic ovary syndrome, and can also be caused by certain types of medications (e.g. long-term steroid use). About 90-95% of all North American cases of diabetes are type 2, and about 20% of the population over the age of 65 is a type 2 diabetic. The fraction of type 2 diabetics in other parts of the world varies substantially, almost certainly for environmental and lifestyle reasons. There is also a strong inheritable genetic connection in type 2 diabetes: having relatives (especially first degree) with type 2 is a considerable risk factor for developing type 2 diabetes. The majority of patients with type 2 diabetes mellitus are obese - chronic obesity leads to increased insulin resistance that can develop into diabetes, most likely because adipose tissue is a (recently identified) source of chemical signals (hormones and cytokines).
Drugs associated with Diabetes, Type 2
The following drugs and medications are in some way related to, or used in the treatment of Diabetes, Type 2. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
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